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Dynamical Control for the Parametric Uncertain Cancer Systems

Yi-Horng Lai, Lan-Yuen Guo, Kun-Ching Wang, and Jau-Woei Perng*
International Journal of Control, Automation, and Systems, vol. 18, no. 9, pp.2411-2422, 2020

Abstract : In this study, we consider a parametric uncertain Lotka–Volterra cancer model including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. The biological parameter (i.e., cell growth rate) is described as a form of the triangular fuzzy number. By using grade mean value conversion, the imprecise fuzzy parameter is translated into the degree of optimism (λ-integral value λ ∈ [0,1]) interval. We derive the sufficient conditions for the existence of the region of asymptotic stability (RAS) in the fuzzy cancer model. The boundary crisis of transient chaos and properties of RAS are investigated under fuzzy environment. We present a dynamical perturbation control to avoid uncontrolled tumor cell growth and prevent healthy cell extinction.

Keyword : Cancer model, Lotka-Volterra system, parametric uncertain system, transient chaos.

 
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